Virtually everyone produces some Lipoprotein(a) in their body which is not considered a problem UNLESS it exceeds 30 mg/dL (or if by the particle test it exceeds 125 nmol/L). Elevated or high Lipoprotein(a), aka Lp(a), is a MUCH greater risk factor for cardiovascular disease than any other lipid factor including high LDL. The Lipoprotein(a) Foundation estimates that 20% of the US population develops more than 30 mg/dL, but doctors usually do NOT test for it unless you ask (probably because there is no med for it).
The medical establishment has long claimed that high Lp(a) is inherited and cannot be significantly reduced. Well, it’s true that the tendency for excessively high Lp(a) IS inherited, but very high doses of niacin are reported to somewhat lower it. I know of two studies using high doses of NIACIN which achieved reductions of 28% and 39% respectively.
Early in my recovery I tried mega-dosing niacin twice but had a very negative side-effect both times. Later I learned I had a genetic mutation that caused “under-methylation” which caused my bad reaction. Suffice to say I did not use niacin (except in very small amount in my multi).
To my surprise, the protocol I developed to treat my cardiovascular disease (and to detox mercury and lead) also happened to work better than anything else I’ve read about for reducing Lp(a). As far as I know, lowering Lp(a) by 61% might be a record.
My lab reports are posted below as evidence.
The first set of blood tests was done 4 months after my diagnosis. I was doing considerable supplements but my blood tests indicated I was still in BIG TROUBLE! My Lp(a) was extremely high risk on both the mass test and particle test. The more significant test is the PARTICLE TEST, on which I was 471 nmol/L – which is almost four times the point at which “very high risk” begins (125nmol/L). (Another test for Lp(a) level is the mass test on which I was 99 mg/dl which was the top of that lab’s scale — so it was probably off the chart.)
One year later I was tested again. That report is also posted below. All of my cholesterol numbers were optimal or moderate, except Lp(a). That time, on the more accurate particle test, it was 184 nmol/L.
Although still high risk, THAT ‘S A 61% REDUCTION!
I had accepted the conventional dogma that high Lp(a) is not reducible. I developed an extensive protocol aimed at treating atherosclerosis and improving overall health. I did NOT specifically try to reduce my Lp(a). SO HOW DID THIS GREAT IMPROVEMENT HAPPEN??
First was diet. I avoided processed foods, no sugar, no soda, no bread, no wheat products, no fruit juice. I ate salads, vegetables but not starchy ones, some whole fruit, avocados, walnuts, coconut oil, olive oil, (but NO polyunsaturated oil such as canola, safflower, corn, soy). My meat was organic chicken and sardines. I regularly ate three organic eggs per day. I bought everything organic if available. No dairy, no alcohol, and even no coffee. I drank filtered water. Avoided over-eating.
In regard to supplements I included anything and everything that my research revealed might help against atherosclerosis (provided no conflicts). I wound up taking a ton of supplements, but part of it was aimed at reducing heavy metals (I had been tested very high in lead and moderately high in mercury) I was spending about $550/month on supplements aimed at atherosclerosis and general health.
I spent about $150/month aimed at reducing heavy metals which may have helped indirectly to treat the atherosclerosis. (I took Chris Shade’s “IMD” binder, chlorella, NAC, etc for that.)
So in a sentence: I did very high amounts of supplements, a rather strict diet, and I exercised regularly, increasing as able – which included sweating out toxins/metals.
No one knows how to really significantly lower Lp(a), but apparently my cover-the-bases approach worked pretty well. For my last blood test in 2017 they did only the mass test (not as accurate) for Lp(a). This year (2018) I told my doc I wanted the Lp(a)-P particle test but he again did the mass test! At least the mass test came back lower then it’s ever been so most likely the particle count had also improved yet some more.
Yes, that’s a lot of supplements and the way I used them may have had something to do also with the positive results achieved. I purchased supps in liquid or powder when possible, but most came in capsules. I would open the selected capsules at each meal and dump the contents which are then taken little by little with water in between bites of food. Thereby the supplements are incorporated into the meal as if part of the nutritional content of the food. Oil soluble vitamins are eaten with fatty food for better absorption.
After that second test posted below, my GP doc and I agreed that I “appear to be cured.” For example, my ability to do strenuous aerobics and weightlifting with no angina pain.
Although I no longer have the symptoms of cardiovascular disease and my Lp(a) is significantly reduced, it is still high (due to genetics). I continue to use supplements, but only at half the types and/or amounts I used for recovery. Of course I still exercise daily.
People ask me more specifically what I did to lower my Lp(a). In regard to diet see my blog post titled “Dietary Suggestions.”
In regard to the $550 worth of supplements/month that I took, which were most important? No one knows for certain, but here is my knowledge-based opinion:
1) mega-dose vitamin C. I took 12 grams/day divided into 3 doses (Now I recommend taking C to bowel tolerance, at least 4 doses per day.)
2) Liposomal C — one gram/day by Livon Labs
3) lysine — 6 grams
4) magnesium glycinate — 600 mg.
5) Vitamin K2 from Thorne liquid K2 (menatetrenone) 30 MILLIGRAMS divided into 3 doses of 10 mg.
6) Vitamin K2 Jarrow mk7 90 mcg
7) Vitamin D3 (test to determine amount)
8) Vitamin A Carlson brand – as retinyl palmitate (take 2-3 times the amount of D3.
9) Vitamin E – “Unique E” 800 IU
10) Megafood multi-vit-min
I took various other antioxidants including turmeric, alpha lipoic acid, R lipoic acid, grapeseed extract.
I did not take l-proline but I do recommend it – 2 grams/day.
I took many more items but those above may be the most important.
Although some people (like me) have inherited extremely high Lp(a) some experts (Dr Methias Rath and Linus Pauling) theorized that Lp(a) is produced to patch damage to the endothelium (inner wall of arteries) which generally occurs due to inflammation along with lack of antioxidants such as vitamin C (Vitamin C is also needed to produce collagen for tissue repair).
Therefore it makes sense that SUFFICIENT IMPROVEMENTS in diet (non-inflammatory foods) and greatly increased intake of various antioxidants including ascorbate (vitamin C) – should cause the body to reduce production of Lp(a). In my case that is basically what I did.
Therefore it seems reasonable that my Lp(a) was reduced by 61% after a year from the time I got my protocol and diet fairly well perfected, especially when you consider that I was not working so I devoted full time to recovery.
So why don’t we hear about similar reductions on Lp(a)? My guess is that not many people are able or willing to put the time, effort, and money that I did. Taking niacin only, or vitamin C only, or l-carnitine only, is not likely to do the job very well.
— Fred Pauser
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